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Before performing below steps, you need to make sure you have pdb files matching dll version on the remote machine.  Open below folder in your remote machine C:\Program Files (x86)\Microsoft Visual Studio\2017\Enterprise\Common7\IDE\Remote Debugger\x64  Open that folder and launch as admin  msvsmon.exe  Select all options to allow firewall From Tools > Options  - Keep the settings to default (as shown below) and click ok.  At this point your remote debugger is all set. You need to connect from Visual Studio by entering Machine IP: Port (4022) 

You might be here because you are getting this misleading error "Assembly must be fully signed (not delay signed)" although you have successfully generated signed dll either locally or from VSO server. I am documenting this specific error scenario here as I couldn't find anything available over the internet.     I had generated fully signed dll using our VSO build definition. When I am uploading this dll to PluginRegistration tool using the assembly “Update” option, it kept throwing the below exception: Unhandled Exception: System.ServiceModel.FaultException`1[[< >]]: Action failed for assembly << TRIMMED >>: Assembly must be fully signed (not delay signed). Detail: … Earlier we were able to update the build generated assembly right from this tool. We are using the task "ESRP CodeSigning" for code signing process. When I checked the history of this definition someone had modified it’s configuration.  So during update

If you are facing below highlighted error detail with PluginRegistration meaning you are trying to register signed/unsigned dll download over the network.  Unhandled Exception: System.IO.FileLoadException: Could not load file or assembly 'file:///C:\Users\\...\xyz.dll' or one of its dependencies. Operation is not supported. ( Exception from HRESULT: 0x80131515)    at System.Reflection.RuntimeAssembly._nLoad(AssemblyName fileName, String codeBase, Evidence assemblySecurity, RuntimeAssembly locationHint, StackCrawlMark& stackMark, IntPtr pPrivHostBinder, Boolean throwOnFileNotFound, Boolean forIntrospection, Boolean suppressSecurityChecks)    at System.Reflection.RuntimeAssembly.InternalLoadAssemblyName(AssemblyName assemblyRef, Evidence assemblySecurity, RuntimeAssembly reqAssembly, StackCrawlMark& stackMark, IntPtr pPrivHostBinder, Boolean throwOnFileNotFound, Boolean forIntrospection, Boolean suppressSecurityChecks)    at System.Reflection.RuntimeAssembly.InternalL